C3.ai DTI is jointly managed and hosted by the University of California, Berkeley and the University of Illinois at Urbana-Champaign, with two physical headquarters on the campuses of UC Berkeley and UIUC.

 Additional academic partners include Carnegie Mellon University, KTH Royal Institute of Technology, Massachusetts Institute of Technology, Princeton University, Stanford University, and University of Chicago.

The Lawrence Berkeley National Laboratory at UC Berkeley and the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign provide supercomputing resources to C3.ai DTI researchers and help advance the Science of Digital Transformation.